The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation.

ABSTRACT:

Background

Implementation of newer anti-tuberculosis (TB) drugs may prolong the QT interval, increasing the risk of arrythmias and sudden cardiac death. The potential for cardiac adverse events has prompted recommendations for frequent cardiac monitoring during treatment. However, unknowns remain, including the association between drug concentrations and QT interval.

Methods

An observational prospective cohort study design was used. Patients undergoing treatment for drug-resistant TB in Georgia were assessed. Serial blood samples were collected at 4-6 weeks for pharmacokinetics. Electrocardiograms were recommended to be performed monthly. A generalized estimating equation spline model was used to investigate (1) the effect difference between bedaquiline and delamanid, (2) th

SUBMITTER: Jin Y 

PROVIDER: S-EPMC10538394 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature