Associations of HIV and antiretroviral therapy with gestational diabetes in South Africa.

ABSTRACT:

Objective

To estimate associations of HIV status and antiretroviral (ART) regimen with gestational diabetes (GDM) and postpartum glucose metabolism.

Design

Prospective cohort study.

Methods

We enrolled pregnant persons with HIV (PWH) and without HIV in Cape Town, South Africa who were at least 18 years of age at 24-28 weeks' gestation and followed up to 26 months postpartum. Participants were tested for GDM in pregnancy and for diabetes postpartum using a 75 g 2 h oral glucose tolerance test (OGTT) and diagnosed via WHO criteria. We estimated associations of HIV status and ART regime [efavirenz (EFV) versus dolutegravir (DTG)] with GDM and postpartum impaired glucose metabolism using multivariable log binomial or linear regression models.

Results

Among 397 part

SUBMITTER: Bengtson AM 

PROVIDER: S-EPMC10538400 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature