Anti-Hebbian plasticity in the motor cortex promotes defensive freezing.

ABSTRACT: Regional brain activity often decreases from baseline levels in response to external events, but how neurons develop such negative responses is unclear. To study this, we leveraged the negative response that develops in the primary motor cortex (M1) after classical fear learning. We trained mice with a fear conditioning paradigm while imaging their brains with standard two-photon microscopy. This enabled monitoring changes in neuronal responses to the tone with synaptic resolution through learning. We found that M1 layer 5 pyramidal neurons (L5 PNs) developed negative tone responses within an hour after conditioning, which depended on the weakening of their dendritic spines that were active during training. Blocking this form of anti-Hebbian plasticity using an optogenetic manipulation of

SUBMITTER: Bai Y 

PROVIDER: S-EPMC10538413 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature