Association of CD4 + cell count and HIV viral load with risk of non-AIDS-defining cancers.

ABSTRACT:

Objectives

HIV-induced immunodeficiency contributes to an increased risk of non-AIDS-defining cancers (NADC). This study aims to identify the most predictive viral load (VL) or CD4 + measures of NADC risk among people with HIV (PWH).

Design

Extracted from South Carolina electronic HIV reporting system, we studied adult PWH who were cancer-free at baseline and had at least 6 months of follow-up since HIV diagnosis between January 2005 and December 2020.

Methods

Using multiple proportional hazards models, risk of NADC was investigated in relation to 12 measures of VL and CD4 + cell count at three different time intervals before NADC diagnosis. The best VL/CD4 + predictor(s) and final model were determined using Akaike's information criterion.

Results

Among 10 413

SUBMITTER: Ma Y 

PROVIDER: S-EPMC10538428 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature