A Simulation of the Effects of Diffusion on Hyperpolarized [1-¹³C]-Pyruvate Signal Evolution.

ABSTRACT:

Objective

Hyperpolarized [1-¹³C]-pyruvate magnetic resonance imaging is an emerging metabolic imaging method that offers unprecedented spatiotemporal resolution for monitoring tumor metabolism in vivo. To establish robust imaging biomarkers of metabolism, we must characterize phenomena that may modulate the apparent pyruvate-to-lactate conversion rate (k_PL). Here, we investigate the potential effect of diffusion on pyruvate-to-lactate conversion, as failure to account for diffusion in pharmacokinetic analysis may obscure true intracellular chemical conversion rates.

Methods

Changes in hyperpolarized pyruvate and lactate signal were calculated using a finite-difference time domain simulation of a two-dimensional tissue model. Signal evolution curves with

SUBMITTER: Patel RJS 

PROVIDER: S-EPMC10538435 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature