Therapeutic role of interleukin-1 receptor antagonist in pancreatic diseases: mendelian randomization study.

ABSTRACT:

Background

The interleukin-1 pathway has been linked to pancreatic diseases. We applied the Mendelian randomization approach to explore whether higher interleukin-1 receptor antagonist (IL-1RA) levels reduce the risk of acute and chronic pancreatitis and pancreatic cancer.

Methods

Genetic variants associated with blood IL-1RA levels at the genome-wide significance level and located 5MB downstream or upstream of the IL1RN gene were extracted from a genome-wide meta-analysis of 21,758 participants. After pruning, genetic variants without linkage disequilibrium were used as genetic instrument for IL-1RA. Summary-level data on acute and chronic pancreatitis and pancreatic cancer were obtained from the UK Biobank and FinnGen studies. The associations were meta-analyzed for

SUBMITTER: Yuan S 

PROVIDER: S-EPMC10538534 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature