A nomogram based on collagen signature for predicting the immunoscore in colorectal cancer.

ABSTRACT:

Objectives

The Immunoscore can categorize patients into high- and low-risk groups for prognostication in colorectal cancer (CRC). Collagen plays an important role in immunomodulatory functions in the tumor microenvironment (TME). However, the correlation between collagen and the Immunoscore in the TME is unclear. This study aimed to construct a collagen signature to illuminate the relationship between collagen structure and Immunoscore.

Methods

A total of 327 consecutive patients with stage I-III stage CRC were included in a training cohort. The fully quantitative collagen features were extracted at the tumor center and invasive margin of the specimens using multiphoton imaging. LASSO regression was applied to construct the collagen signature. The association of the collagen

SUBMITTER: Jiang W 

PROVIDER: S-EPMC10538535 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature