3D printing-based frugal manufacturing of glass pipettes for minimally invasive delivery of therapeutics to the brain.

ABSTRACT:

Objective

Intracerebral delivery of agents in liquid form is usually achieved through commercially available and durable metal needles. However, their size and texture may contribute to mechanical brain damage. Glass pipettes with a thin tip may significantly reduce injection-associated brain damage but require access to prohibitively expensive programmable pipette pullers. This study is to remove the economic barrier to the application of minimally invasive delivery of therapeutics to the brain, such as chemical compounds, viral vectors, and cells.

Methods

We took advantage of the rapid development of free educational online resources and emerging low-cost 3D printers by designing an affordable pipette puller (APP) to remove the cost obstacle.

Results

We showed that

SUBMITTER: Qiao G 

PROVIDER: S-EPMC10538625 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature