Recombulator-X: A fast and user-friendly tool for estimating X chromosome recombination rates in forensic genetics.

ABSTRACT: Genetic markers (especially short tandem repeats or STRs) located on the X chromosome are a valuable resource to solve complex kinship cases in forensic genetics in addition or alternatively to autosomal STRs. Groups of tightly linked markers are combined into haplotypes, thus increasing the discriminating power of tests. However, this approach requires precise knowledge of the recombination rates between adjacent markers. The International Society of Forensic Genetics recommends that recombination rate estimation on the X chromosome is performed from pedigree genetic data while taking into account the confounding effect of mutations. However, implementations that satisfy these requirements have several drawbacks: they were never publicly released, they are very slow and/or need cluster-le

SUBMITTER: Aneli S 

PROVIDER: S-EPMC10538763 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature