Hypoglycemia in children and young adults with cystic fibrosis during oral glucose tolerance testing vs. continuous glucose monitoring.

ABSTRACT:

Background

Hypoglycemia is common in people with cystic fibrosis (pwCF) during oral glucose tolerance tests (OGTTs) and in the free-living setting, yet its pathophysiology remains unclear.

Objective

To evaluate hypoglycemia in children and young adults with CF by OGTT and continuous glucose monitoring (CGM).

Methods

A 3-h OGTT was performed in children and young adults with CF and healthy controls (HC). Individuals were classified as experiencing hypoglycemia on OGTT (glucose <70 mg/dL) or not. Insulin, C-peptide, glucose, glucagon, and incretins were measured. CGM was performed for 7 days in the free-living setting. Measures of insulin sensitivity, beta cell function accounting for insulin sensitivity, and insulin clearance were calculated.

Results

A total of

SUBMITTER: Finn E 

PROVIDER: S-EPMC10538856 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature