Effectiveness of HCC surveillance programs using multitarget blood test: A modeling study.

ABSTRACT:

Background

The effectiveness of ultrasound-based surveillance for HCC in patients with cirrhosis is limited by suboptimal sensitivity for early tumor detection and poor adherence. Emerging blood-based biomarkers have been proposed as an alternative surveillance strategy. We aimed to evaluate the comparative effectiveness of a multitarget HCC blood test (mt-HBT)-with and without improved adherence-against ultrasound-based HCC surveillance.

Methods

We developed a Markov-based mathematical model that simulated a virtual trial in patients with compensated cirrhosis comparing potential surveillance strategies: biannual surveillance using ultrasound, ultrasound plus AFP, and mt-HBT with or without improved adherence (+10% increase). We used published data to inform underlying live

SUBMITTER: Chhatwal J 

PROVIDER: S-EPMC10538878 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature