Oxidized and Unsaturated: Key Organic Aerosol Traits Associated with Cellular Reactive Oxygen Species Production in the Southeastern United States.

ABSTRACT: Exposure to ambient fine particulate matter (PM_2.5) is associated with millions of premature deaths annually. Oxidative stress through overproduction of reactive oxygen species (ROS) is a possible mechanism for PM_2.5-induced health effects. Organic aerosol (OA) is a dominant component of PM_2.5 worldwide, yet its role in PM_2.5 toxicity is poorly understood due to its chemical complexity. Here, through integrated cellular ROS measurements and detailed multi-instrument chemical characterization of PM in urban southeastern United States, we show that oxygenated OA (OOA), especially more-oxidized OOA, is the main OA type associated with cellular ROS production. We further reveal that highly unsaturated species containing carbon-oxygen double bonds and

SUBMITTER: Liu F 

PROVIDER: S-EPMC10538939 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature