Comparison of model-free Lorentzian and spinlock model-based fittings in quantitative CEST imaging of acute stroke.

ABSTRACT:

Purpose

CEST MRI detects complex tissue changes following acute stroke. Our study aimed to test if spinlock model-based fitting of the quasi-steady-state (QUASS)-reconstructed equilibrium CEST MRI improves the determination of multi-pool signal changes over the commonly-used model-free Lorentzian fitting in acute stroke.

Theory and methods

Multiple three-pool CEST Z-spectra were simulated using Bloch-McConnell equations for a range of T₁ , relaxation delay, and saturation times. The multi-pool CEST signals were solved from the simulated Z-spectra to test the accuracy of routine Lorentzian (model-free) and spinlock (model-based) fittings without and with QUASS reconstruction. In addition, multiparametric MRI scans were obtained in rat models of acute stroke, includ

SUBMITTER: Wu L 

PROVIDER: S-EPMC10538953 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature