Frailty, Guideline-Directed Medical Therapy, and Outcomes in HFrEF: From the GUIDE-IT Trial.

ABSTRACT:

Objectives

In this study, we sought to evaluate the association of frailty with the use of optimal guideline-directed medical therapy (GDMT) and outcomes in heart failure with reduced ejection fraction (HFrEF).

Background

The burden of frailty in HFrEF is high, and the patterns of GDMT use according to frailty status have not been studied previously.

Methods

A post hoc analysis of patients with HFrEF enrolled in the GUIDE-IT (Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment in Heart Failure) trial was conducted. Frailty was assessed with the use of a frailty index (FI) using a 38-variable deficit model, and participants were categorized into 3 groups: class 1: nonfrail, FI <0.21); class 2: intermediate frailty, FI 0.21-0.31), and class 3: high frai

SUBMITTER: Khan MS 

PROVIDER: S-EPMC10539014 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature