Sex differences in endocannabinoid tone in a pilot study of cannabis use disorder and acute cannabis abstinence.

ABSTRACT: Cannabis use disorder (CUD) presents differently in men and women, particularly in symptoms of cannabis withdrawal. Novel pharmacotherapeutic interventions for CUD, such as those that target the endocannabinoid (eCB) system, must be developed in a manner consistent with these sex differences. The present pilot study sought to prospectively assess sex differences in cannabis withdrawal in a small sample of adults with moderate-to-severe CUD and to determine if withdrawal was associated with peripheral eCB and eCB congener tone. Men and women (n = 5/sex) completed 2 weeks of study participation separated by 1 month; in the latter week, participants abstained from cannabis use. Each week, participants attended in-person laboratory visits during which blood was drawn repeatedly to assess plasm

SUBMITTER: Martin EL 

PROVIDER: S-EPMC10539022 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature