Nanoparticle-Templated Molecular Recognition Platforms for Detection of Biological Analytes.

ABSTRACT: Molecular recognition of biological analytes with optical nanosensors provides both spatial and temporal biochemical information. A recently developed sensing platform exploits near-infrared fluorescent single-wall carbon nanotubes combined with electrostatically pinned heteropolymers to yield a synthetic molecular recognition technique that is maximally transparent through biological matter. This molecular recognition technique is known as corona phase molecular recognition (CoPhMoRe). In CoPhMoRe, the specificity of a folded polymer toward an analyte does not arise from a pre-existing polymer-analyte chemical affinity. Rather, specificity is conferred through conformational changes undergone by a polymer that is pinned to the surface of a nanoparticle in the presence of an analyte and th

SUBMITTER: Beyene AG 

PROVIDER: S-EPMC10539024 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature