Potential Impact of Pharmacogenomic Single Nucleotide Variants in a Rural Caucasian Population.

ABSTRACT:

Background

In the US adverse drug reactions (ADRs) are estimated to cause 100 000 fatalities and cost over $136 billion annually. A patient's genes play a significant role in their response to a drug. Pharmacogenomics aims to optimize drug choice and dose for individual patients by characterizing patients' pharmacologically relevant genes to identify variants of known impact.

Methods

DNA was extracted from randomly selected remnant whole blood samples from Caucasian patients with previously performed complete blood counts. Samples were genotyped by mass spectrometry using a customized pharmacogenomics panel. A third-party result interpretation service used genotypic results to predict likely individual responses to frequently prescribed drugs.

Results

Complete genotyp

SUBMITTER: Williams GR 

PROVIDER: S-EPMC10539040 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature