Critically ill patients with acute kidney injury: clinical determinants and post-mortem histology.

ABSTRACT:

Background

Acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) portends a poor prognosis. We aimed to better characterize predictors of survival and the mechanism of kidney failure in these patients.

Methods

This was a retrospective observational study using clinical and radiological electronic health records, analysed by univariable and multivariable binary logistic regression. Histopathological examination of post-mortem renal tissue was performed.

Results

Among 157 patients with AKI requiring RRT, higher serum creatinine at RRT initiation associated with increased ICU survival [odds ratio (OR) 0.33, 95% confidence interval (CI) 0.17-0.62, P = .001]; however, muscle mass (a marker of frailty) interacted with cr

SUBMITTER: Gleeson PJ 

PROVIDER: S-EPMC10539222 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature