Causal Associations Between Gut Microbiota and Psoriasis: A Mendelian Randomization Study.

ABSTRACT:

Introduction

Previous studies have proposed a possible gut-skin axis, and linked gut microbiota to psoriasis risks. However, there is heterogeneity in existing evidence. Observational research is prone to bias, and it is hard to determine causality. Therefore, this study aims to evaluate possible causal associations between gut microbiota (GM) and psoriasis.

Methods

With published large-scale GWAS (genome-wide association study) summary datasets, two-sample Mendelian randomization (MR) was performed to sort out possible causal roles of GM in psoriasis and arthropathic psoriasis (PsA). The inverse variance weighted (IVW) method was taken as the primary evaluation of causal association. As complements to the IVW method, we also applied MR-Egger, weighted median. Sensitivity an

SUBMITTER: Zang C 

PROVIDER: S-EPMC10539234 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature