Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis.

ABSTRACT:

Background

The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in the blood. As some of these factors are strongly correlated, it is important to evaluate the independent effects they may have on survival.

Methods

Tumour samples from 2162 CRC patients were visually assessed for amount of tumour stroma, severity of lymphocytic infiltrate at the tumour margins and the presence of lymphoid follicles. Somatic mutations in the tumour were assessed for 2134 individuals. Pre-surgical levels of 4963 plasma proteins were measured in 128 individuals. The associations between these features and prognosis were inspected by a Cox Proportiona

SUBMITTER: Magnusson MI 

PROVIDER: S-EPMC10539279 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature