Acetylation reprograms MITF target selectivity and residence time.

ABSTRACT: The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis. How this is achieved is poorly understood. The microphthalmia-associated transcription factor MITF is a lineage-survival oncogene that plays a crucial role in melanocyte development and melanoma. MITF suppresses invasion, reprograms metabolism and promotes both proliferation and differentiation. How MITF distinguishes between differentiation and proliferation-associated targets is unknown. Here we show that compared to many transcription factors MITF exhibits a very long residence time which is reduced by p300/CBP-mediated MITF acetylation at K206. While K206 acetylation also decreas

SUBMITTER: Louphrasitthiphol P 

PROVIDER: S-EPMC10539308 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature