A comprehensive appraisal of HER2 heterogeneity in HER2-amplified and HER2-low colorectal cancer.

ABSTRACT:

Background

This study aimed to elucidate the clinicopathological and molecular features of HER2-amplified and HER2-low colorectal cancers (CRCs). We also characterised HER2 expression statuses in CRCs focusing on their intratumoral heterogeneity and alterations in metastatic lesions to establish practical HER2 status assessment.

Methods

We evaluated 1009 CRCs for HER2 expression and HER2 amplification by immunohistochemistry and FISH, respectively, and correlated the results to clinicopathological and molecular data. For HER2-positive tumours, HER2 expression in metastatic lesions was also assessed.

Results

Twenty-five HER2-amplified (2.5%) and 46 HER2-low tumours (4.6%) were identified. HER2-amplified tumours consistently lacked a mucinous component and HER2-low tumo

SUBMITTER: Hashimoto T 

PROVIDER: S-EPMC10539373 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature