Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application.

ABSTRACT: The topology type and the functionalization of pores play an important role in regulating the performance of covalent organic frameworks. Herein, we designed and synthesized the covalent organic framework with hetero-environmental pores using predesigned asymmetrical dialdehyde monomer. According to the results of structural characterization, crystallinity investigation, and theoretical calculation, the hetero-environmental pores of the obtained framework are regarded as the alternant arrangement. The distinctive hetero pore structure leads the designed material to show more advantages as compared with control materials in loading both hydrophobic and hydrophilic antibiotics for wound healing. This dual-antibiotic strategy can expand the antibacterial range as compared with the single anti

SUBMITTER: Ji W 

PROVIDER: S-EPMC10539374 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature