Colon Adenoma After Diagnosis of Immune Checkpoint Inhibitor-mediated Colitis.

ABSTRACT: Purpose: While the occurrence of colitis during immune checkpoint inhibitor (ICI) treatment is recognized as a sign of robust immune activation and correlates with better oncological outcomes, the long-term impact of ICI-mediated colitis on the colonic mucosa has not been studied. We thus aim to describe the colonoscopy and histology findings in patients at a follow-up time of ≥ 6 months post initial colitis event. Methods: This retrospective analysis included adult cancer patients diagnosed with ICI colitis at a tertiary cancer center between October 2013 and June 2020. The study group included patients diagnosed with immune mediated colitis who had also undergone a follow up colonoscopy or flex sigmoidoscopy. The control group was patients exposed to ICI without immune medi

SUBMITTER: Machado AP 

PROVIDER: S-EPMC10539391 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature