Dual enhancement in the radiosensitivity of prostate cancer through nanoparticles and chemotherapeutics.

ABSTRACT:

Background

Radiotherapy (RT) is an essential component in the treatment regimens for many cancer patients. However, the dose escalation required to improve curative results is hindered due to the normal tissue toxicity that is induced. The introduction of radiosensitizers to RT treatment is an avenue that is currently being explored to overcome this issue. By introducing radiosensitizers into tumor sites, it is possible to preferentially enhance the local dose deposited. Gold nanoparticles (GNPs) are a potential candidate that have shown great promise in increasing the radiosensitivity of cancer cells through an enhancement in DNA damage. Furthermore, docetaxel (DTX) is a chemotherapeutic agent that arrests cells in the G2/M phase of the cell cycle, the phase most sensitive to radi

SUBMITTER: Jackson N 

PROVIDER: S-EPMC10539438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature