Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α₂-adrenoceptor and trace amine-associated receptor 1 ligand.

ABSTRACT:

Background

α₂-adrenoceptor ligands have been investigated as potential therapeutic agents for the treatment of obesity. Our previous studies have shown that guanabenz reduces the body weight of obese rats, presumably through its anorectic action. This demonstrates an additional beneficial effect on selected metabolic parameters, including glucose levels. The purpose of this present research was to determine the activity of guanabenz's metabolite-4-hydroxy guanabenz hydrochloride (4-OH-Guanabenz).

Methods

We performed in silico analyses, involving molecular docking to targets of specific interest as well as other potential biological targets. In vitro investigations were conducted to assess the selectivity profile of 4-OH-Guanabenz binding to α-adrenoceptors, along

SUBMITTER: Kotanska M 

PROVIDER: S-EPMC10539439 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature