Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands.

ABSTRACT:

Background

Although the terms "agonist" and "antagonist" have been used to classify sigma-1 receptor (σ₁R) ligands, an unambiguous definition of the functional activity is often hard. In order to determine the pharmacological profile of σ₁R ligands, the most common method is to assess their potency to alleviate opioid analgesia. It has been well established that σ₁R agonists reduce opioid analgesic activity, while σ₁R antagonists have been demonstrated to enhance opioid analgesia in different pain models.

Methods

In the present study, we evaluated the pharmacological profile of selected σ₁R ligands using a novel object recognition (NOR) test, to see if any differences in cognitive functions between σ₁R agonist

SUBMITTER: Szczepanska K 

PROVIDER: S-EPMC10539447 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature