PM_2.5 induced liver lipid metabolic disorders in C57BL/6J mice.

ABSTRACT: PM_2.5 can cause adverse health effects via several pathways, such as inducing pulmonary and systemic inflammation, penetration into circulation, and activation of the autonomic nervous system. In particular, the impact of PM_2.5 exposure on the liver, which plays an important role in metabolism and detoxification to maintain internal environment homeostasis, is getting more attention in recent years. In the present study, C57BL/6J mice were randomly assigned and treated with PM_2.5 suspension and PBS solution for 8 weeks. Then, hepatic tissue was prepared and identified by metabolomics analysis and transcriptomics analysis. PM_2.5 exposure can cause extensive metabolic disturbances, particularly in lipid and amino acids metabolic dysregulation.128 d

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10539470 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature