VEGFA Promotes Skeletal Muscle Regeneration in Aging.

ABSTRACT: Aging is associated with loss of skeletal muscle regeneration. Differentially regulated vascular endothelial growth factor (VEGF)A with aging may partially underlies this loss of regenerative capacity. To assess the role of VEGFA in muscle regeneration, young (12-14 weeks old) and old C57BL/6 mice (24,25 months old) are subjected to cryoinjury in the tibialis anterior (TA) muscle to induce muscle regeneration. The average cross-sectional area (CSA) of regenerating myofibers is 33% smaller in old as compared to young (p < 0.01) mice, which correlates with a two-fold loss of muscle VEGFA protein levels (p = 0.02). The capillary density in the TA is similar between the two groups. Young VEGF^lo mice, with a 50% decrease in systemic VEGFA activity, exhibit a two-fold reduction in the

SUBMITTER: Endo Y 

PROVIDER: S-EPMC10539483 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature