Rhs NADase effectors and their immunity proteins are exchangeable mediators of inter-bacterial competition in Serratia.

ABSTRACT: Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial effector proteins into neighbouring bacterial cells, representing an important mechanism of inter-bacterial competition. Specific immunity proteins protect bacteria from the toxic action of their own effectors, whilst orphan immunity proteins without a cognate effector may provide protection against incoming effectors from non-self competitors. T6SS-dependent Rhs effectors contain a variable C-terminal toxin domain (CT), with the cognate immunity protein encoded immediately downstream of the effector. Here, we demonstrate that Rhs1 effectors from two strains of Serratia marcescens, the model strain Db10 and clinical isolate SJC1036, possess distinct CTs which both display NAD(P)⁺ glycohydrolas

SUBMITTER: Hagan M 

PROVIDER: S-EPMC10539506 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature