Opioids and immune checkpoint inhibitors differentially regulate a common immune network in triple-negative breast cancer.

ABSTRACT:

Background

Opioids are the primary analgesics for cancer pain. Recent clinical evidence suggests opioids may counteract the effect of immune checkpoint inhibition (ICI) immunotherapy, but the mechanism for this interaction is unknown. The following experiments study how opioids and immunotherapy modulate a common RNA expression pathway in triple negative breast cancer (TNBC), a cancer subtype in which immunotherapy is increasingly used. This study identifies a mechanism by which opioids may decrease ICI efficacy, and compares ketamine, a non-opioid analgesic with emerging use in cancer pain, for potential ICI interaction.

Methods

Tumor RNA expression and clinicopathologic data from a large cohort with TNBC (N=286) was used to identify RNA expression signatures of disease. Va

SUBMITTER: Scarpa JR 

PROVIDER: S-EPMC10539607 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature