Detecting anisotropic segmental dynamics in disordered proteins by cross-correlated spin relaxation.

ABSTRACT: Among the numerous contributions of Geoffrey Bodenhausen to NMR spectroscopy, his developments in the field of spin-relaxation methodology and theory will definitely have a long lasting impact. Starting with his seminal contributions to the excitation of multiple-quantum coherences, he and his group thoroughly investigated the intricate relaxation properties of these "forbidden fruits" and developed experimental techniques to reveal the relevance of previously largely ignored cross-correlated relaxation (CCR) effects, as "the essential is invisible to the eyes". Here we consider CCR within the challenging context of intrinsically disordered proteins (IDPs) and emphasize its potential and relevance for the studies of structural dynamics of IDPs in the future years to come. Conventionally, d

SUBMITTER: Kauffmann C 

PROVIDER: S-EPMC10539831 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature