Expression of microRNA-379 reduces metastatic spread of prostate cancer.

ABSTRACT:

Introduction

Prostate cancer (PCa) is the most common type of cancer in males, and the metastatic form is a leading cause of death worldwide. There are currently no curative treatments for this subset of patients. To decrease the mortality of this disease, greater focus must be placed on developing therapeutics to reduce metastatic spread. We focus on dissemination to the bone since this is both the most common site of metastatic spread and associated with extreme pain and discomfort for patients. Our strategy is to exploit microRNAs (miRNAs) to disrupt the spread of primary PCa to the bone.

Methods

PCa cell lines were transduced to overexpress microRNA-379 (miR-379). These transduced PCa cells were assessed using cell growth, migration, colony formation and adhesion assays.

SUBMITTER: Cassidy JR 

PROVIDER: S-EPMC10539900 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature