Mutations on a conserved distal enhancer in the porcine C-reactive protein gene impair its expression in liver.

ABSTRACT: C-reactive protein (CRP) is an evolutionary highly conserved protein. Like humans, CRP acts as a major acute phase protein in pigs. While CRP regulatory mechanisms have been extensively studied in humans, little is known about the molecular mechanisms that control pig CRP gene expression. The main goal of the present work was to study the regulatory mechanisms and identify functional genetic variants regulating CRP gene expression and CRP blood levels in pigs. The characterization of the porcine CRP proximal promoter region revealed a high level of conservation with both cow and human promoters, sharing binding sites for transcription factors required for CRP expression. Through genome-wide association studies and fine mapping, the most associated variant

SUBMITTER: Hernandez-Banque C 

PROVIDER: S-EPMC10539928 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature