Activation of Toll-like receptor 4 by thyroid hormone triggers abnormal B-cell activation.

ABSTRACT:

Objective

Breakdown of tolerance and abnormal activation of B cells is an important mechanism in the pathogenesis of Graves' disease (GD). High levels of thyroid hormones (THs) play important roles in GD progression. However, the interactions between THs and abnormal activation of B cells remain elusive. This study aimed to explore the effect of high levels of THs on TLR4 expression and abnormal B cell differentiation.

Materials and methods

Blood samples were collected from patients with GD and healthy controls (HCs) to evaluate the frequency of B cells, their subsets, and TLR4 expression in B cells. A high-level T3 mouse model was used to study the interaction between THs and the TLR4 signalling pathway.

Results

We found that the frequencies of CD19⁺ , CD1

SUBMITTER: Wang J 

PROVIDER: S-EPMC10540142 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature