BEaTS-β: an open-source electromechanical bioreactor for simulating human cardiac disease conditions.

ABSTRACT: Heart disease remains the leading cause of worldwide mortality. Although the last decades have broadened our understanding of the biology behind the pathologies of heart disease, ex vivo systems capable of mimicking disease progression and abnormal heart function using human cells remain elusive. In this contribution, an open-access electromechanical system (BEaTS-β) capable of mimicking the environment of cardiac disease is reported. BEaTS-β was designed using computer-aided modeling to combine tunable electrical stimulation and mechanical deformation of cells cultured on a flexible elastomer. To recapitulate the clinical scenario of a heart attack more closely, in designing BEaTS-β we considered a device capable to operate under hypoxic conditions. We tested human induced pluripot

SUBMITTER: Takaya H 

PROVIDER: S-EPMC10540188 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature