High CD8⁺tumor-infiltrating lymphocytes indicate severe exhaustion and poor prognosis in angioimmunoblastic T-cell lymphoma.

ABSTRACT:

Background

Exhaustion of CD8⁺ tumor-infiltrating lymphocytes (TILs), characterized by the overexpression of immune checkpoints (IC), is a major impediment to anti-tumor immunity. However, the exhaustion status of CD8⁺TILs in angioimmunoblastic T cell lymphoma (AITL) remains unclear. Therefore, we aimed to elucidate the exhaustion status of CD8⁺TILs in AITL and its influence on prognosis.

Methods

The correlation between CD8⁺TILs and IC expression in AITL was analyzed using single-cell RNA sequencing (n = 2), flow cytometry (n = 20), and RNA sequencing (n = 20). Biological changes related to CD8⁺TILs exhaustion at different cytotoxic T lymphocyte (CTL) levels (mean expression levels of CD8A, CD8B, GZMA, GZMB, and PRF1) in

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10540231 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature