Transient Dynamic Operation of G-Quadruplex-Gated Glucose Oxidase-Loaded ZIF-90 Metal-Organic Framework Nanoparticle Bioreactors.

ABSTRACT: Glucose oxidase-loaded ZIF-90 metal-organic framework nanoparticles conjugated to hemin-G-quadruplexes act as functional bioreactor hybrids operating transient dissipative biocatalytic cascaded transformations consisting of the glucose-driven H₂O₂-mediated oxidation of Amplex-Red to resorufin or the glucose-driven generation of chemiluminescence by the H₂O₂-mediated oxidation of luminol. One system involves the fueled activation of a reaction module leading to the temporal formation and depletion of the bioreactor conjugate operating the nickase-guided transient biocatalytic cascades. The second system demonstrates the fueled activation of a reaction module yielding a bioreactor conjugate operating the exonuclease III-dictated transient operation

SUBMITTER: Qin Y 

PROVIDER: S-EPMC10540265 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature