Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.

ABSTRACT:

Introduction

It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging.

Methods

Diffusion MRI data from several well-established longitudinal cohorts of aging (Alzheimer's Disease Neuroimaging Initiative [ADNI], Baltimore Longitudinal Study of Aging [BLSA], Vanderbilt Memory & Aging Project [VMAP]) were free-water corrected and harmonized. This dataset included 1723 participants (age at baseline: 72.8 ± 8.87 years, 49.5% male) and 4605 imaging sessions (follow-up time: 2.97 ± 2.09 years, follow-up range: 1-13 years, mean number of visits: 4.42 ± 1.98). Differences in white matter microstructural decline in normal and abnormal agers was assessed.

Results

While we found a global decline in white matter in normal/abnor

SUBMITTER: Archer DB 

PROVIDER: S-EPMC10540270 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature