Comparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis.

ABSTRACT:

Background

Metastases within liver or the brain are the most common causes of mortality from lung cancer (LC). Predicting liver or brain metastases before having evidence from imaging of the tumors is challenging but important for early patient intervention. According to mounting evidence, exosomes circulating within blood may facilitate cancer spread by transporting certain proteins for target cells.

Methods

Using liquid chromatography-MS/MS, we investigated the plasma exosomes' proteomic profiles derived from 42 metastatic LC patients [16 solitary liver metastasis (LM), together with 26 solitary brain metastasis (BM)] and 25 local advanced (LA) lung cancer cases without metastasis, together with five healthy controls (HC), assessing the LM and BM pathogenesis and find pote

SUBMITTER: Li S 

PROVIDER: S-EPMC10540327 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature