Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice.

ABSTRACT:

Background

In addition to social and cultural factors, sex differences in the central nervous system have a critical influence on behavior, although the neurobiology underlying these differences remains unclear. Interestingly, the Locus Coeruleus (LC), a noradrenergic nucleus that exhibits sexual dimorphism, integrates signals that are related to diverse activities, including emotions, cognition and pain. Therefore, we set-out to evaluate sex differences in behaviors related to LC nucleus, and subsequently, to assess the sex differences in LC morphology and function.

Methods

Female and male C57BL/6J mice were studied to explore the role of the LC in anxiety, depressive-like behavior, well-being, pain, and learning and memory. We also explored the number of noradrenergic LC c

SUBMITTER: Mariscal P 

PROVIDER: S-EPMC10540344 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature