A simplified bacterial community found within the epidermis than at the epidermal surface of atopic dermatitis patients and healthy controls.

ABSTRACT: There has been considerable research into the understanding of the healthy skin microbiome. Similarly, there is also a considerable body of research into whether specific microbes contribute to skin disorders, with atopic dermatitis (AD) routinely linked to increased Staphylococcus aureus (S. aureus) colonisation. In this study, the epidermal surface of participants was sampled using swabs, while serial tape-stripping (35 tapes) was performed to sample through the stratum corneum. Samples were taken from AD patients and healthy controls, and the bacterial communities were profiled by metabarcoding the universal V3-V4 16S rRNA region. Results show that the majority of bacterial richness is located within the outermost layers of the stratum corneum, however there were many taxa that were fou

SUBMITTER: Barnes CJ 

PROVIDER: S-EPMC10540355 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature