In vitro trypanocidal activity of extracts and compounds isolated from Vitellaria paradoxa.

ABSTRACT:

Background

Vitellaria paradoxa is used in traditional medicine for the treatment of various diseases in tropical countries; however, nothing is known about its anti-trypanosomal activity. Human African trypanosomiasis is a neglected tropical disease of Sub-Saharan Africa's poorest rural regions, and the efficacy of its treatment remains a challenge. This study investigates the as-yet-unknown trypanocidal activity of this plant.

Methods

V. paradoxa, commonly known as shea tree, was selected for study based on an ethnobotanical investigation. Ultrasonicated extracts from bark and seeds were successively treated with ethyl acetate and water. Column chromatography, NMR spectroscopy and mass spectrometry were used to identify isolated compounds. Purified trypanosomes (Trypanosoma

SUBMITTER: Bairy G 

PROVIDER: S-EPMC10540432 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature