Combined use of CDAI and blood indices for assessing endoscopic activity in ileocolic Crohn's disease.

ABSTRACT:

Background

Mucosal healing has become the primary treatment target for patients with Crohn's disease (CD). We aimed to develop a noninvasive and convenient tool to evaluate the endoscopic activity in patients with ileocolic CD.

Methods

A retrospective multicenter study including 300 CD patients (training, 210 patients; test, 90 patients) was conducted at two tertiary referral centers. Independent risk factors associated with endoscopic activity were explored, which were then combined into a comprehensive index. The predictive performance was evaluated with the area under receiver operating characteristic curve (ROC). Cohen's Kappa was adopted to examine the consistency between each indicator and endoscopic activity.

Results

A total of 210 CD patients were recruited in

SUBMITTER: Hu X 

PROVIDER: S-EPMC10540500 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature