Redox/pH-responsive hollow manganese dioxide nanoparticles for thyroid cancer treatment.

ABSTRACT: The nano drug delivery system MnO₂/CDDP@PDA-Cy5.5 was synthesized in this study to increase the efficacy of Cisplatin (CDDP) on thyroid cancer and alleviate the damage to normal tissue, with the aim of enhancing the anti-cancer efficacy, increasing the drug load, optimizing the control of drug release, and alleviating the systemic toxicity arising from drug off-target. On that basis, high efficacy and low toxicity win-win can be obtained. In this study, hollow manganese dioxide nanoparticles (MnO₂ NPs) were prepared based on the template method. CDDP was loaded into the hollow cavity and then modified with polydopamine (PDA) and Cy5.5, with the aim of obtaining the nano-drug loading system MnO₂/CDDP@PDA-Cy5.5 NPs. The NPs precisely delivered drugs by intell

SUBMITTER: Liu J 

PROVIDER: S-EPMC10540626 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature