Campylobacter jejuni benefits from the bile salt deoxycholate under low-oxygen condition in a PldA dependent manner.

ABSTRACT: Enteric bacteria need to adapt to endure the antibacterial activities of bile salts in the gut. Phospholipase A (PldA) is a key enzyme in the maintenance of bacterial membrane homeostasis. Bacteria respond to stress by modulating their membrane composition. Campylobacter jejuni is the most common cause of human worldwide. However, the mechanism by which C. jejuni adapts and survives in the gut environment is not fully understood. In this study, we investigated the roles of PldA, bile salt sodium deoxycholate (DOC), and oxygen availability in C. jejuni biology, mimicking an in vivo situation. Growth curves were used to determine the adaptation of C. jejuni to bile salts. RNA-seq and functional assays were employed to investigate the PldA-dependent and DOC-

SUBMITTER: Cao X 

PROVIDER: S-EPMC10540661 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature