Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disease affecting 7-10 million people worldwide. Currently, there is no treatment available to prevent or delay PD progression, partially due to the limited understanding of the pathological events which lead to the death of dopaminergic neurons in the substantia nigra in the brain, which is known to be the cause of PD symptoms. The current available treatments aim at compensating dopamine (DA) deficiency in the brain using its precursor levodopa, dopaminergic agonists and some indirect dopaminergic agents. The immune system is emerging as a critical player in PD. Therefore, immune-based approaches have recently been proposed to be used as potential antiparkinsonian agents. It has been well-known that dopaminergic pathways play a signi

SUBMITTER: Furgiuele A 

PROVIDER: S-EPMC10540835 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature