Lithium isotopes differentially modify mitochondrial amorphous calcium phosphate cluster size distribution and calcium capacity.

ABSTRACT: Lithium is commonly prescribed as a mood stabilizer in a variety of mental health conditions, yet its molecular mode of action is incompletely understood. Many cellular events associated with lithium appear tied to mitochondrial function. Further, recent evidence suggests that lithium bioactivities are isotope specific. Here we focus on lithium effects related to mitochondrial calcium handling. Lithium protected against calcium-induced permeability transition and decreased the calcium capacity of liver mitochondria at a clinically relevant concentration. In contrast, brain mitochondrial calcium capacity was increased by lithium. Surprisingly, ⁷Li acted more potently than ⁶Li on calcium capacity, yet ⁶Li was more effective at delaying permeability transition

SUBMITTER: Deline ML 

PROVIDER: S-EPMC10540846 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature