Prioritising cardiovascular disease risk assessment to high risk individuals based on primary care records.

ABSTRACT:

Objective

To provide quantitative evidence for systematically prioritising individuals for full formal cardiovascular disease (CVD) risk assessment using primary care records with a novel tool (eHEART) with age- and sex- specific risk thresholds.

Methods and analysis

eHEART was derived using landmark Cox models for incident CVD with repeated measures of conventional CVD risk predictors in 1,642,498 individuals from the Clinical Practice Research Datalink. Using 119,137 individuals from UK Biobank, we modelled the implications of initiating guideline-recommended statin therapy using eHEART with age- and sex-specific prioritisation thresholds corresponding to 5% false negative rates to prioritise adults aged 40-69 years in a population in England for invitation to a formal CVD

SUBMITTER: Chung R 

PROVIDER: S-EPMC10540947 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature