Prevalence and risk factors of M tuberculosis infection in young people across 14 communities in Zambia and South Africa.

ABSTRACT:

Background

From 2018-2021 the TB Reduction through Expanded Antiretroviral Treatment and TB Screening (TREATS) project took place in 21 Zambian and South African communities. The TREATS Incidence of TB Infection Cohort Study was conducted in adolescents and young people (AYP), aged 15-24 years in 14 communities. We describe the baseline prevalence and risk factors of Mycobacterium tuberculosis (M. tuberculosis) infection among this cohort and explore the quantitative QFT-Plus interferon gamma (IFN-γ) responses.

Methods and findings

A random sample of approximately 300 AYP per community were recruited and information on TB/HIV risk factors, TB symptoms and social mixing patterns collected. QuantiFERON TB Gold Plus assay (QFT-Plus) was used to detect M. tuberculosis infection,

SUBMITTER: Amofa-Sekyi M 

PROVIDER: S-EPMC10540968 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature